Click to purchase Horse Chestnut – Aesculus Hippocastanum

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NOTE: These indications are only for use with embryonic plant stem cell tissues. Adult plants do not have the same constituents, actions or applications in most cases.

The Aesculus hippocastanum is a large deciduous tree that is native to Asia and northern Greece and is now cultivated in many areas of Europe and North America. This rapidly growing tree reaches heights of 98 feet and has a wide spread and broadly conical crown. The Aesculus hippocastanum is easily distinguishable by its 5 to 7 fingered, bright-green leaflets appearing on each stiff green stem in early spring. Once the tree is fully leafed out in late spring, masses of upright flower spikes blossom around its canopy. The flowers of this showy arrangement are scented, pink and white, and 8 inches high. Ripening of this tree’s fruit occurs in early autumn. The spiny-husked fruit splits open when mature, revealing two large chestnut brown seeds known as buckeyes, conkers, or horse chestnuts.

Common uses of this tree include dye, soap, starch, tannin, wood.

Bach flower applications: Useful for someone who fails to learn by experience; someone who lacks observation to learn life’s lessons (repeating errors since childhood). For those who are more concerned for the well-being and safety of others, especially family and close friends, than they are for themselves. The positive quality of this remedy is the return of a more rational concern. These applications also apply to Plant Stem Cell Therapy.

Abstracts of Published Research on Horse Chestnut – Aesculus Hippocastanum:

1. Altern Med Rev. 2009 Sep;14(3):278-83.
Aesculus hippocastanum (Horse chestnut) – Monograph.[No authors listed]

2. Planta Med. 2009 Jul 3. [Epub ahead of print] Escin, a Natural Mixture of Triterpene Saponins, Exhibits Antitumor Activity Against Hepatocellular Carcinoma.Zhou XY, Fu FH, Li Z, Dong QJ, He J, Wang CH.

3. Tidsskr Nor Laegeforen. 2009 Feb 26;129(5):420-2.
Horse chestnut–remedy for chronic venous insufficiencyMethlie CB, Schjøtt J.

4. Vascul Pharmacol. 2008 Oct-Dec;49(4-6):158-65. Epub 2008 Jul 30.
Effect of beta-escin sodium on endothelial cells proliferation, migration and apoptosis.Wang XH, Xu B, Liu JT, Cui JR.

5. J Pharm Pharmacol. 2008 Sep;60(9):1213-20.
Beta-escin, a natural triterpenoid saponin from Chinese horse chestnut seeds, depresses HL-60 human leukaemia cell proliferation and induces apoptosis.Niu YP, Wu LM, Jiang YL, Wang WX, Li LD.

6. J Agric Food Chem. 2008 Jun 25;56(12):4783-8. Epub 2008 May 31.
Antiobese effects of novel saponins from edible seeds of Japanese horse chestnut (Aesculus turbinata BLUME) after treatment with wood ashes.Kimura H, Ogawa S, Katsube T, Jisaka M, Yokota K.

7. Int J Cosmet Sci. 1999 Dec;21(6):437-47
Horse Chestnut – Aesculus Hippocastanum: Potential Applications in Cosmetic Skin-care Products.Wilkinson JA, Brown AM.

8. Int J Cosmet Sci. 2007 Apr;29(2):140.
A horse chestnut extract, which induces contraction forces in fibroblasts, is a potent anti-aging ingredient.Fujimura T, Tsukahara K, Moriwaki S, Hotta M, Kitahara T, Takema Y.

9. Leuk Lymphoma. 2008 Jul;49(7):1384-91
Beta-aescin: a potent natural inhibitor of proliferation and inducer of apoptosis in human chronic myeloid leukemia K562 cells in vitro.Niu YP, Li LD, Wu LM.

10. Chem Pharm Bull (Tokyo). 2008 Jan;56(1):12-6.
Anti-obesity effects of escins extracted from the seeds of Aesculus turbinata BLUME (Hippocastanaceae).Hu JN, Zhu XM, Han LK, Saito M, Sun YS, Yoshikawa M, Kimura Y, Zheng YN.

11. J Vet Med Sci. 2007 Jul;69(7):709-12.
Identification of COX inhibitors in the hexane extract of Japanese horse chestnut (Aesculus turbinata) seeds.Sato I, Kofujita H, Tsuda S.

12. J Cosmet Sci. 2006 Sep-Oct;57(5):369-76.
A horse chestnut extract, which induces contraction forces in fibroblasts, is a potent anti-aging ingredientFujimura T, Tsukahara K, Moriwaki S, Hotta M, Kitahara T, Takema Y.

13. J Vet Med Sci. 2006 May;68(5):487-9.
Antiinflammatory effect of Japanese horse chestnut (Aesculus turbinata) seeds.Sato I, Kofujita H, Suzuki T, Kobayashi H, Tsuda S.

14. Adv Ther. 2006 Jan-Feb;23(1):179-90.
Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: a review of 5 clinical studies.Suter A, Bommer S, Rechner J.

15. Ostomy Wound Manage. 2006 Apr;52(4):68-70, 72-4, 76-8.
Using horsechestnut seed extract in the treatment of venous leg ulcers: a cost-benefit analysis.Leach MJ, Pincombe J, Foster G.

16. J Pharm Biomed Anal. 2006 Aug 28;41(5):1657-65. Epub 2006 Apr 18.
Identification of novel saponins from edible seeds of Japanese horse chestnut (Aesculus turbinata Blume) after treatment with wooden ashes and their nutraceutical activity.Kimura H, Ogawa S, Jisaka M, Kimura Y, Katsube T, Yokota K.

17. J Wound Care. 2006 Apr;15(4):159-67.
Clinical efficacy of horsechestnut seed extract in the treatment of venous ulceration.Leach MJ, Pincombe J, Foster G.

18. J Vet Med Sci. 2005 Jul;67(7):731-4.
Antioxidative and antigenotoxic effects of Japanese horse chestnut (Aesculus turbinata) seeds.Sato I, Suzuki T, Kobayashi H, Tsuda S.

19. Drugs Aging. 1999 Dec;15(6):423-8.
Herbal medications for common ailments in the elderly.Ernst E.

20. Boll Soc Ital Biol Sper. 1989 Feb;65(2):137-41.
Steroidal constituents and anti-inflammatory activity of the horse chestnut (Aesculus hippocastanum L.) bark.Senatore F, Mścisz A, Mrugasiewicz K, Gorecki P.

21. J Nat Prod. 1986 Jul-Aug;49(4):650-6.Links
Antitumor agents, 82. Cytotoxic sapogenols from Aesculus hippocastanum.Konoshima T, Lee KH


Cu, Cr, Fe, Ge, Mg, Mn, Na, Ni, Si, Sr, Ti, Zn.

Vitamins and Minerals:

Calcium, Choline.

Phytochemical Constituents:

Acetic-Acid, Acylated Glycosides, Triterpene Saponins collectively known as Aescin. Aesculetin, Adenine, Adenosine, Allantoin, Angelic-Acid, Astragalin, Barringtogenol-C21-angelate (terpenoid), Campesterol, Citric-Acid, Cryptoaescin, Epicatechin, Escin, Esculetin, Esculin, Fraxetin, Fraxin, Glucuronic-Acid, Guanine, Hippocaesculin (terpenoid), Isoquercitrin, Kaempferol-3-Rhamnoglucoside, Leucocyanidin, Leucodelphinidin, Myricetine, Protoaesigenin, Quercetin, Quercitrin, Rutin, Saponins, Scopoletin, Scopoline, Starch, Sterols Sitosterol, Stigmasterol, Tannin.

Saponins, a complex mixture known as “aescin”, are composed of acylated glycosides of protoaesigenin and barringtogenol-C and include hippocaesculin and many others. Barringtogenol-C21-angelate (terpenoid), hippocaesculin (terpenoid).

Coumarin glycosides aesculin, fraxin, and scopoline and their corresponding aglycones, aesculetin, fraxetin, and scopoletin, are also found, along with flavonoids such as quercitrin. Allantoin, leucocyanidins, tannins, and the plant sterols sitosterol, stigmasterol, and campesterol have also been identified.

Plant Stem Cell Therapy Indications:
Polycrest all Bipolar action!

Cardio Vascular System:

Regulatory Bipolar Action for Hypertension and Hypotension, Venous decongestant. Hemorrhoids (anti-hemorrhaging), sedative action and antispasmodic, Varicosities, Varicose Veins, Broken Capillaries, spider veins, Telangiectasis. Chronic Venous Insufficiency CVI. Deep Vein Thrombosis. Prevents blood from pooling in the legs and feet. Help support the normal integrity of the vascular system and connective tissue. Haemocompatible surfaces of stents keeps them clean of accumulation within the stent as with the drug Plavix but not superior to dogwood for this effect but a great adjuvant.Aescin reduces transcapillary filtration of water and protein and increases venous tone by increasing the vasoconstrictor, prostaglandin F2 alpha. It stabilizes cholesterol-containing membranes of lysosomes and limits the release of enzymes, which is typically increased in chronic pathologic conditions of the vein. It also improves vascular resistance and aids toning of vein walls. The triterpene glycosides and steroid saponins decrease venous capillary permeability and appear to have a tonic effect on the circulatory system.Rutin inhibits platelet aggregation, making the blood thinner and improving circulation. Scopoletin (7-Hydroxy-6-methoxycoumarin)Significantly decreases in lower-leg volume and reduction of leg circumference at the calf and ankleLeucocyanidin capillariprotective antioxidant potencyand vascular-protective actionCryptoaescin, Aescin, Aesculetin, Escin, Esculetin, Esculin, Fraxetin, Fraxin, Hippocaesculin AHaemocompatible surfaces of stents keeps them clean of accumulation within the stent as with the drug Plavix but not superior to that of Dogwood which is the polycrest for stent proper maintenance.

Pulmonary System:

COPD, Emphysema, Pulmonary Insufficiency, Dilatation of the Bronchus, a long standing asthma. Shortness of breath. Triad: Hazel – Corylus Avellana (buds), Horse Chestnut – Aesculus Hippocastanum (buds), Wayfaring Tree – Viburnum Lantana (buds).


Blotchiness of the face & Erythema Peri-ulcerative, Hematomas.

Topical Use: Skin ulcers, wound, scalds, burns and sunburns, carbuncles, acne and skin eruptions, pruritus, fissures and abrasions, impetigo, eczema, psoriasis.

Hematology Oncology:

The internal Detergent for blood detoxification. Anticoagulant, Cytotoxic activity in the 9-KB (human nasopharyngeal carcinoma). Barringtogenol-C21-angelate (saponin): Antiproliferative activity; cytotoxic; antitumor against nasopharyngeal carcinoma. Anti-inflammatory actions have been documented for the saponins (aescin). Aesculetin (esculin), a hydroxycoumarin, may increase bleeding time. May prolong Activated Clotting Time (ACT); Partial Thromboplastin Time (PTT); Prothrombin Consumption Time (PCT); Fibrinogen; Coagulation Factors; Platelet Count; Platelet Function. Formal name: Prothrombin Time and International Normalized Ratio (INR).

GI – Digestive – Hepatology:

Inhibits the growth of Escherichia coli, which is responsible for intestinal infections, and Helicobacter pylori, which causes ulcers.


Regulates the hormone high or low serotonin, which helps to reduce anxiety and depression.

Warning: Horse chestnut has an anti-clotting action, people taking medications such as Coumadin, Plavix or Ticlid, as well as those who use aspirin therapy to reduce blood clotting, should avoid the use of horse chestnut.


Assists in the proper detoxification of plastic-hardening chemical called hydroxylated diphenylalkanes or Bisphenols A BPA, similar to the hormone estrogen, is used to seal canned food and make shatterproof bottles. It is also used in hundreds of household items, from sunglasses to CDs. Bisphenol-A has been found to interrupt the functioning of the hormone system which is linked to reproductive complications, early onset of puberty, liver and thyroid damage and testicular cancer. Polyvinyl chloride Phthalates are chemicals added to plastic to make it soft and flexible these toxic chemicals are easily released. Phthalates can leak out of the plastic toys and enter their vulnerable bodies and systems. Auxins Indole-3 acetic acid(IAA) which detoxifies excess xenoestrogens. Glucuronic-Acid which Antidote (Camphor); and (Morphine); Antihepatotoxic; Detoxicant. Removes Toxins and Excess Xenoestrogens. Saponins bind with bile salt and cholesterol in the intestinal tract. Saponins cause a reduction of blood cholesterol by preventing its re-absorption. Saponins seem to react with the cholesterol rich membranes of cancer cells, thereby limiting their growth and viability.

Xenoestrogens a synthetic substances that imitate the effects of estrogens, such as bisphenols and phthalates maybe one of the cause to contribute to the dramatic decline in bioavailable testosterone and sperm count that has been observed in American men over the past 50 years. This same period has coincided with a meteoric rise in the incidence of diabetes and heart disease in the US.

Optimizing testosterone levels may provide men with powerful protection against the risk of premature death and diseases such as diabetes, heart disease, osteoporosis, Alzheimer’s, and even prostate cancer.

References: LE Magazine July 2007: Edward M. Lichten, MD, FACS, is a Fellow of the American College of Surgeons and a Fellow of the American College of Obstetricians and Gynecologists.

Warnings : Orally administered aescin has an absorption half-life of about 1 hour and an elimination half-life of about 20 hours. May prolong APTT, PTT, INR. Horse chestnut has an anti-clotting action, people taking medications such as Coumadin, Plavix or Ticlid, as well as those who use aspirin therapy to reduce blood clotting, should avoid the use of horse chestnut. This plant in the adult stage is potentially toxic contaminated with toxic metals if ingested and should not be used internally contrary to the embryonic form which is completely safe and non toxic.